Clinical Trials & Research

Reviewed by Emily Henderson, B.Sc.Sep 24 2020 Researchers have identified two antibodies that protect mice against lethal infections of influenza B virus, report scientists at Washington University School of Medicine in St. Louis and Icahn School of Medicine at Mount Sinai. Together with an antibody that targets the other major kind of influenza viruses that
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The coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), placed many countries into lockdown during the peak of the pandemic. Now, many nations have re-opened businesses to boost their economies, which have been negatively impacted by the outbreak. With many countries lifting restrictions, and some schools opening their face-to-face classes,
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Currently, researchers are studying the characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as the host immune responses, in order to come up with better options for preventive and therapeutic approaches to containing this pandemic. A new study by the Argentinian AntiCovid Consortium and published in the preprint server bioRxiv* in September
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Using mouse models, scientists have investigated the active plasma metabolite of remdesivir, GS-441 524, and hydroxychloroquine as possible drug candidates in COVID-19. The research shows GS-441 524 could be an effective therapeutic drug against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while at the same time discounting hydroxychloroquine as a reliable anti-viral. Scientists worldwide are
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Reviewed by Emily Henderson, B.Sc.Sep 19 2020 Take a sniff of a freshly poured glass of wine, and the prevailing scientific thinking would suggest that the harmony of fragrances you perceive starts with sensory receptors in your nose simply adding up the individual odors they encounter. However, new research from Kyushu University shows that a
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Modeling indicates that secondary structures of RNA in the genes encoding the Nsp4 and Nsp16 proteins of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are different from other related coronavirus species, and this may affect some viral molecular processes. With the dramatic spread of COVID-19 caused by the SARS-CoV-2 coronavirus, there has been a
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Reviewed by Emily Henderson, B.Sc.Sep 16 2020 In the first week of the coronavirus pandemic, people living in the United States underestimated their chances of catching the virus, or of getting seriously ill from the virus, according to a recently published Caltech-led study. But as the days progressed, those same people became more worried about
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Reviewed by Emily Henderson, B.Sc.Sep 15 2020 Addressing the risks that Covid-19 infection may cause to a pregnant woman, particularly to placenta and fetus, is the aim of a new study of the R&D&I group “Maternal-fetal medicine, epigenetics, women’s diseases and reproductive health” of the Biomedical Research Institute of Malaga (IBIMA), which received EUR 10,000
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Researchers at the University of Georgia in the United States have shed light on the pathological mechanisms underlying the association between the genetic locus 3p21.31 and severe coronavirus disease 2019 (COVID-19). Although 3p21.31 is known to be a major genetic locus involved in severe COVID-19, until now, the underlying pathological mechanisms and target genes involved
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Reviewed by Emily Henderson, B.Sc.Sep 11 2020 Previously, Chen-Yu Zhang’s group have identified SID1 transmembrane family member 1 (SIDT1) as a critical membrane protein mediating dietary miRNAs absorption, which is abolished in SIDT1 deficient mice. In the present study, they demonstrate a significant frequency of human population (16%) that carry a SIDT1 polymorphism with amino
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Sep 11 2020 Osteoporosis, a bone disease linked to ageing, is characterized by a loss of bone density, micro-architectural deterioration of the bones and an increased risk of fractures. With one third of postmenopausal women affected, it is a major public health problem. Through epidemiological analyses, laboratory experiments and state-of-the-art metagenomic and metabolomics tools, a
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A recent study by researchers at the Max Planck Institute for Infection Biology, the Institut Pasteur and the Centre International de Recherche en Infectiologie (CIRI) suggests that the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is influenced by influenza virus infection during the initial period of coronavirus disease 2019 (COVID-19) pandemic in Europe.
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Reviewed by Emily Henderson, B.Sc.Sep 9 2020 The diets of hunter-gatherers are changing at a fast pace, as in the contemporary world, they are increasingly being deprived of their access to land and natural resources and urged to adapt to sedentary lifestyle. An interdisciplinary study from the University of Helsinki brings forth the underlying causes
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Reviewed by Emily Henderson, B.Sc.Sep 7 2020 As the world scrambles to control the growing COVID-19 coronavirus pandemic, new research in Nature Structural & Molecular Biology shows viruses also play a key evolutionary role in mammals’ ability to reproduce and survive. Scientists in the Cincinnati Children’s Perinatal Institute and at Azabu University in Japan obtained
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With the use of an accurate high throughput assay, researchers from the Weizmann Institute of Science and Magen David Adom Blood Services in Israel showed substantial inter-individual variability and antibody cross-reactivity against seasonal coronaviruses upon SARS-CoV-2 infection, with important implications for immune surveys and vaccines. The study is currently available on the medRxiv* preprint server.
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Reviewed by Emily Henderson, B.Sc.Sep 5 2020 In a newly published paper, the authors first paint the vision of what optimal patient advocacy can do to overcome the challenges described by kidney transplant patients and donors and then describe how to make that vision a reality, especially during the COVID-19 pandemic. Dr. Amy Waterman, Deputy
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Reviewed by Emily Henderson, B.Sc.Sep 4 2020 In contrast to WHO´s and other expert´s advice, the worst-off countries should be extra prioritised when it comes to COVID-19 vaccine allocation, according to Professor Ole Frithjof Norheim at the University of Bergen. Once effective COVID-19 vaccines are approved, they will be scarce. WHO and others have promised
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Reviewed by Emily Henderson, B.Sc.Sep 3 2020 Performing acts of kindness and helping other people can be good for people’s health and well-being, according to research published by the American Psychological Association. But not all good-hearted behavior is equally beneficial to the giver. The strength of the link depends on many factors, including the type
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Reviewed by Emily Henderson, B.Sc.Sep 1 2020 Biological sex influences the effect of amyloid beta on alterations to tau protein characteristic to Alzheimer’s disease, suggesting a role for estradiol in preventing the disease in women, report scientists in the Journal of Alzheimer’s Disease Alzheimer’s disease (AD) is the most common neurodegenerative disease and the leading
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Reviewed by Emily Henderson, B.Sc.Aug 31 2020 In a major public health success, the introduction of pneumococcal conjugate vaccine PCV13, or Prevnar 13, in 2010 in the United States is associated with reduction in socioeconomic disparities and the near elimination of Black-white-based racial disparities for invasive pneumococcal disease. That’s according to an upcoming study in
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Researchers from Sechenov University together with Russian and Iranian colleagues described currently known approaches to the treatment of SARS-CoV-2 infection. In the paper published in Journal of Molecular Medicine, they wrote about how different groups of drugs worked and how promising each approach was. SARS-CoV-2 – a coronavirus that caused the pandemic in early 2020
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The U.S. Food and Drug Administration announced that a public meeting of the Vaccines and Related Biological Products Advisory Committee will be held on CutOct. 22, 2020, to discuss the general matter of the development, authorization, and/or licensure of vaccines indicated to prevent COVID-19. The FDA has scheduled a meeting of its Vaccines and Related
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